VR Stimulation of Exercise Response in Sedentary Humans

Part of paid clinical trials in Detroit, Michigan.

Sponsor
Wayne State University
Study ID
NCT07296991
Status
Recruiting
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Conditions

  • Metabolic Syndrome
  • Prolonged Inactivity

Eligibility Criteria

Sex
ALL
Age
25 Years - 40 Years
Healthy Volunteers
Not accepted

Interventions

  • 20 minutes cycling exercise — BEHAVIORAL
    20 minutes cycling exercise
  • Virtual Reality — BEHAVIORAL
    20 minutes virtual cycling

Study Details

Prolonged sedentary conditions contribute to declining health across human populations and cause significant secondary health consequences for many patients whose illnesses or injuries prevent them from exercising. The investigators have demonstrated that in a small animal fruit fly model, genetic stimulation of neurons that promote adrenergic signaling is sufficient to mimic the benefits of exercise training even in sedentary animals. The investigator's pilot work in humans has confirmed that humans respond to Virtual Reality (VR) stimuli that mimic exercise by increasing heart rate and altering heart rate variability in a way consistent with increased adrenergic activity. In this study, the investigators will directly test for the first time whether repeated, controlled exposure to VR stimuli that induce adrenergic activity in sedentary humans can produce adaptive changes to protein expression and endurance performance like those produced by actual exercise in pre-diabetic participants with/without hypertension.

Key Dates

Start date
Sep 30, 2025
Status verified
Dec 2025
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
48 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: EX-20 minutes sub max cycling exercise
    20 minutes cycling exercise
  • Experimental: VR-virtual reality exercise
    20 minutes virtual cycling
  • Active Comparator: VR+: 20 minutes sub max cycling exercise + virtual reality
    20 minutes cycling exercise + 20 minutes virtual cycling

Primary Outcome Measure

Blood Glucose, HbA1C [ Time Frame: 10 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wayne State UniversityDetroitMichigan48201
Alyson Sujkowski, PhD
[email protected]
419-461-4317
Robert J Wessells, PhD
[email protected]
734-476-4325

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By research site
Wayne State University· Detroit, MI

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