Exercise Effects on Adipose Tissue Structure and Function

Part of paid clinical trials in Ann Arbor, Michigan.

Sponsor
University of Michigan
Study ID
NCT04812314
Status
Recruiting
Apply to this trial

Conditions

  • Insulin Resistance
  • Metabolic Disease
  • Metabolic Syndrome
  • Obesity
  • Weight Gain
  • Weight Loss

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Not accepted

Interventions

  • Exercise — BEHAVIORAL
    Participants will complete a moderate intensity continuous exercise 4 days/week.
  • No exercise — BEHAVIORAL
    Participants will remain sedentary throughout the duration of the study.

Study Details

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.

Key Dates

Start date
Mar 1, 2021
Status verified
Jun 2026
Primary completion
Mar 1, 2028
Completion
Mar 1, 2030

Study Design

Enrollment
46 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Exercise
    This exercise prescription represents a common or "conventional" form of physical activity (e.g., moderate/brisk walking). If assigned to this group, participants will perform 45 minutes of moderate intensity continuous steady-state exercise at 70% maximal heart rate (HRmax) to expend 250 calories 4 days per week.
  • Experimental: No exercise
    Subjects assigned to this group are to remain sedentary (no planned physical exercise) throughout the duration of the study.

Primary Outcome Measure

Oral Glucose Tolerance Test (OGTT) [ Time Frame: 2 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MichiganAnn ArborMichigan48109
Jeffrey F Horowitz
[email protected]
7346471076

Find similar trials in Ann Arbor, MI

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Michigan· Ann Arbor, MI

Related Studies