Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Study ID
NCT07278388
Status
Recruiting
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Conditions

  • Fatigue
  • PASC Post Acute Sequelae of COVID 19

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Physical Fatigue — BEHAVIORAL
    Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.

Study Details

This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.

Key Dates

Start date
Jul 16, 2025
Status verified
Dec 2025
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
200 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: PASC Participants - Physical Fatigue Task
    Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.
  • Experimental: Control Participants - Physical Fatigue Task
    Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.

Primary Outcome Measure

Comparison between PASC and HC - difference in mean Assessment Error [ Time Frame: Baseline, during experimental protocol. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Kennedy Krieger InstituteBaltimoreMaryland21201
Anthony Gonzalez
[email protected]
443-923-2716

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By research site
Kennedy Krieger Institute· Baltimore, MD

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