Methadone in THA for Post-op Pain and Opioid Reduction

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07227064
Phase
PHASE3
Status
Recruiting
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Conditions

  • Post Operative Pain
  • Total Hip Arthroplasty

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Methadone — DRUG
    Patients will intraoperatively receive methadone 0.15mg/kg IV, based on ideal body weight.

Study Details

This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea/vomiting, and quality of recovery. A total of 162 subjects will be enrolled at MUSC surgical sites.

Key Dates

Start date
Jan 12, 2026
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Jan 31, 2027

Study Design

Enrollment
162 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Methadone
    Patients will intraoperatively receive methadone 0.15mg/kg IV, based on ideal body weight.
  • No Intervention: No Methadone
    Patients will NOT receive methadone.

Primary Outcome Measure

Patient reported pain in the recovery unit after surgery [ Time Frame: up to 24 hours after surgery ends ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425
Haley Nitchie, MHA
[email protected]
843-792-1869

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By research site
Medical University of South Carolina· Charleston, SC

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