Methadone in TKA for Post-op Pain and Opioid Reduction

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07226076
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • Post Operative Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Methadone Hydrochloride — DRUG
    Patients will intraoperatively be administered methadone 0.15mg/kg IV, based on ideal body weight.

Study Details

This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.

Key Dates

Start date
Jan 8, 2026
Status verified
Feb 2026
Primary completion
Dec 28, 2026
Completion
Jan 15, 2027

Study Design

Enrollment
162 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Methadone
    Patients will intraoperatively receive methadone 0.15mg/kg IV, based on ideal body weight.
  • No Intervention: No Methadone
    Patients will NOT receive methadone.

Primary Outcome Measure

Patient reported pain in the recovery unit after surgery [ Time Frame: up to 24 hours after surgery ends ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425
Haley Nitchie, MHA
[email protected]
843-792-1869

Find similar trials in Charleston, SC

By research site
Medical University of South Carolina· Charleston, SC

Related Studies