Recovery of Physical Function After Critical Illness In Older Adults

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
University of Kentucky
Study ID
NCT07225257
Status
Recruiting
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Conditions

  • Acute Lung Injury(ALI)
  • Sepsis

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Accepted

Study Details

The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.

Key Dates

Start date
Mar 11, 2026
Status verified
May 2026
Primary completion
Jun 1, 2030
Completion
Dec 31, 2031

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: RETURN
    Survivors of critical illness

Primary Outcome Measure

Muscle Strength measured by Chair Rise Test [ Time Frame: Baseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Kentucky, Lexington, Kentucky 40536LexingtonKentucky40536
Doug A Long, MS
[email protected]
8593231100
Kirby P Mayer, DPT, Ph.D. (PRINCIPAL_INVESTIGATOR)
Esther Dupont-Versteegden, Ph.D. (SUB_INVESTIGATOR)

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University of Kentucky, Lexington, Kentucky 40536· Lexington, KY

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