K08 VR Fear Conditioning

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT07216222
Status
Enrolling By Invitation

Conditions

  • Anxiety and Fear
  • PTSD
  • Veteran

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Deep Brain Stimulation — DEVICE
    Deep brain stimulation via the Responsive Neurostimulator (RNS) device.

Study Details

The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment. The study will also look at how brain activity and body responses are connected to learning and memory of fear. To do so, we recruit individuals who are already implanted with a Responsive Neurostimulator (RNS) device for the treatment of epilepsy. This research may help improve our understanding of anxiety disorders and how to better treat them in the future. The main questions it aims to answer are: 1) How do people learn to associate certain cues in VR with feelings of fear or safety? 2) What brain and body responses happen during fear learning? Participants will: 1) Wear a virtual reality headset and experience different environments and sounds, 2) Have their brain activity, heart rate, and sweating measured, and 3) Receive safe, mild electrical pulses through the RNS device during the study to help study fear learning. Participants will attend one or more study sessions, each lasting about 3-4 hours.

Key Dates

Start date
Mar 1, 2025
Status verified
Oct 2025
Primary completion
Mar 1, 2028
Completion
Feb 28, 2030

Study Design

Enrollment
70 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: All RNS Participants
    In this single-arm study, all participants will complete identical experimental conditions with simultaneous iEEG recordings (Recording Study) or iEEG stimulation (Stimulation Study).

Primary Outcome Measure

Intracranial EEG activity [ Time Frame: Baseline ]

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA Semel Institute for Neuroscience and Human BehaviorLos AngelesCalifornia90024-

Find similar trials in Los Angeles, CA

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
UCLA Semel Institute for Neuroscience and Human Behavior· Los Angeles, CA

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