Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT07166120
Status
Recruiting
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Conditions

  • Physician's Role
  • Smoking
  • Smoking Cessation

Eligibility Criteria

Sex
ALL
Age
18 Years - 89 Years
Healthy Volunteers
Not accepted

Interventions

  • Usual care — BEHAVIORAL
    Usual care will be informed by practice guidelines (standard of care, brief advice, and guideline awareness).
  • Precision treatment — BEHAVIORAL
    Precision treatment will be informed by practice guidelines (standard of care, brief advice, and guideline awareness), plus patient-specific risk feedback and personalized tobacco treatment recommendations using patients' clinical, genetic, and biomarker information, adapted for oncology.

Study Details

This study evaluates the feasibility and preliminary effects of precision tobacco treatment, compared to usual care, on promoting tobacco treatment in oncology patients and providers in the oncology care setting. The precision treatment intervention includes personalized tobacco treatment recommendations using the patient's clinical, genetic, and biomarker information. This intervention may increase patient receipt of tobacco treatment, patient medication use, and patient smoking abstinence at 6 months.

Key Dates

Start date
Sep 11, 2025
Status verified
Oct 2025
Primary completion
Mar 31, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
112 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Usual Care
    The arm will represent usual care in the oncology care clinics. Clinicians will receive a report designed to recommend guideline-based tobacco treatment. Patients will receive a report on guideline-based advice about smoking cessation and a brief discussion with a behavior interventionist.
  • Experimental: PrecisionTx-Onc (oncology)
    Clinicians will receive PrecisionTx-Onc, an intervention designed to recommend precision tobacco treatment, adapted for oncology. Patients will receive PrecisionTx-Onc, an intervention designed to recommend precision tobacco treatment, and a brief discussion with a behavior interventionist, adapted for oncology.

Primary Outcome Measure

Patient receipt of tobacco treatment medication for smoking cessation [ Time Frame: 6 months post-intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of MedicineSt LouisMissouri63110
Li-Shiun Chen, ScD, M.D., MPH
[email protected]
314-362-3932
Theodore Thomas, M.D.
[email protected]
Li-Shiun Chen, ScD, M.D., MPH (PRINCIPAL_INVESTIGATOR)
Ramaswamy Govindan, M.D. (SUB_INVESTIGATOR)
Theodore Thomas, M.D. (SUB_INVESTIGATOR)

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Washington University School of Medicine· St Louis, MO

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