Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT05627674
Status
Enrolling By Invitation

Conditions

  • Smoking
  • Smoking Cessation
  • Tobacco Use Cessation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Usual Care — BEHAVIORAL
    Usual care incorporates guideline awareness and brief advice.
  • RiskProfile-Clin — BEHAVIORAL
    RiskProfile-Clin incorporates standard brief advice and guideline awareness plus specific patient risk feedback using clinical factors.
  • RiskProfile-Gen — BEHAVIORAL
    RiskProfile-Gen incorporates standard brief advice and guideline awareness plus specific patient risk feedback using clinical factors and genetic factors.

Study Details

This trial tests the effects of two versions of RiskProfile, a clinically-informed and a genetically-informed version of a patient-specific risk feedback tool, in comparison to usual care, on lung cancer screening and tobacco treatment. The trial assesses the multilevel effects of these precision risk feedback tools on the likelihood of clinicians to order lung cancer screening and tobacco treatment and of their patients to utilize these cancer prevention interventions.

Key Dates

Start date
Jan 1, 2023
Status verified
Dec 2025
Primary completion
Aug 31, 2027
Completion
Aug 31, 2028

Study Design

Enrollment
915 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Usual Care
    Annual lung cancer screening with low-dose computed tomography (LDCT) is currently recommended in the U.S. for at-risk patients. Tobacco treatment and cessation is recommended for patients who smoke.
  • Experimental: RiskProfile-Clin
    RiskProfile-Clin is a clinically-informed risk feedback tool to activate cancer risk-reducing behaviors.
  • Experimental: RiskProfile-Gen
    RiskProfile-Gen is a genetically-informed risk feedback tool to activate cancer risk-reducing behaviors.

Primary Outcome Measure

Clinician ordering of lung cancer screening [ Time Frame: From enrollment through 6 months post-intervention ]

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of MedicineSt LouisMissouri63110-

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By research site
Washington University School of Medicine· St Louis, MO

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