Personalized Tobacco Treatment in Primary Care (MOTIVATE)

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT05846841
Status
Recruiting
Apply to this trial

Conditions

  • Physician's Role
  • Smoking
  • Smoking Cessation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Precision Treatment — BEHAVIORAL
    Precision treatment will be informed by practice guidelines (standard of care, brief advice, and guideline awareness), plus patient-specific risk feedback and personalized tobacco treatment recommendations using patients' clinical, genetic, and biomarker information.
  • Usual Care — BEHAVIORAL
    Usual care will be informed by practice guidelines (standard of care, brief advice, and guideline awareness).

Study Details

This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobacco treatment recommendations using the patient's clinical, genetic, and biomarker information. This approach may increase effectiveness and adherence for the patient, and increase the clinician's likelihood of prescribing.

Key Dates

Start date
Sep 29, 2023
Status verified
Feb 2026
Primary completion
Mar 31, 2028
Completion
Sep 30, 2028

Study Design

Enrollment
850 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Usual Care
    The arm will represent usual care in the primary care clinics. Physicians will receive a report designed to recommend guideline-based tobacco treatment. Patients will receive a report on guideline-based advice about smoking cessation and a brief discussion with a behavior interventionist.
  • Experimental: PrecisionTx
    Physicians will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment. Patients will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment, and a brief discussion with a behavior interventionist.

Primary Outcome Measure

Patient receipt of tobacco treatment medication for smoking cessation [ Time Frame: 6 months post-intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of MedicineSt LouisMissouri63110
Li-Shiun Chen, ScD, MD, MPH
[email protected]
314-362-3932
Alex Ramsey, PhD
[email protected]
314-362-5370
Li-Shiun Chen, ScD, MD, MPH (PRINCIPAL_INVESTIGATOR)
Alex Ramsey, PhD (PRINCIPAL_INVESTIGATOR)
Laura Bierut, MD (SUB_INVESTIGATOR)
Esther Lu, PhD (SUB_INVESTIGATOR)
Robert Schnoll, PhD (SUB_INVESTIGATOR)
Timothy Baker, PhD (SUB_INVESTIGATOR)
Hilary Tindle, MD (SUB_INVESTIGATOR)
Rachel Tyndale, PhD (SUB_INVESTIGATOR)

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Washington University School of Medicine· St Louis, MO

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