Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

Part of paid clinical trials in Alabaster, Alabama.

Sponsor
Vertex Pharmaceuticals Incorporated
Study ID
NCT07161037
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • VX-407 — DRUG
    Tablets for oral administration.

Study Details

The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of VX-407.

Key Dates

Start date
Nov 19, 2025
Status verified
Nov 2025
Primary completion
Jul 22, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
24 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: VX-407
    Participants will receive VX-407 for up to 52 weeks.

Primary Outcome Measure

htTKV on MRI Over Time [ Time Frame: Baseline up to End of Study (Week 52) ]

Central Contacts

Locations (26)

FacilityCityStateZIPSite coordinators
Alabama Kidney ResearchAlabasterAlabama35007-
UAB Nephrology Research at CH19BirminghamAlabama35294-
Kaiser Permanente Los Angeles Medical CenterLos AngelesCalifornia90027-
UCSF Clinical Research Center at ParnassusSan FranciscoCalifornia94143-
Nephrology & Hypertension Associates, PCMiddleburyConnecticut06762-
Yale University - Yale Nephrology Clinical Research ClinicNew HavenConnecticut06510-
Mayo Clinic - JacksonvilleJacksonvilleFlorida32224-
Emory School of Medicine - Renal DivisionAtlantaGeorgia30322-
Renal AssociatesColumbusGeorgia31904-
UChicago Medicine - Duchossois Center for Advanced Medicine - NephrologyChicagoIllinois60637-
University of Iowa Health Care Medical Center- NephrologyIowa CityIowa52242-
Clinical & Translational Science Unit (CTSU) - NephrologyKansas CityKansas66160-
University of Maryland Medical Center - General Clinical Research CenterBaltimoreMaryland21201-
Beth Israel Deaconess Medical Center - NephrologyBostonMassachusetts02215-
Tufts Medical CenterBostonMassachusetts02111-
University of Minnesota -Clinics and Surgery Center (CSC) - Endocrine ClinicMinneapolisMinnesota55455-
Mayo Clinic - RochesterRochesterMinnesota55905-
DaVita Kidney Care - Las VegasLas VegasNevada89107-
General Nephrology Clinic - New York CityNew YorkNew York10032-
The Rogosin Kidney CenterNew YorkNew York10021-
Cleveland Clinic - Main CampusClevelandOhio44195-
Geisinger ClinicDanvillePennsylvania17822-
Perelman Center for Advanced Medicine - NephrologyPhiladelphiaPennsylvania19104-
Nephrology Clinical Trials CenterNashvilleTennessee37232-
UVM Medical Center - 1 South Prospect StreetBurlingtonVermont05401-
Swedish Center for Comprehensive CareSeattleWashington98104-

Find similar trials in Alabaster, AL

By research site
Alabama Kidney Research· Alabaster, ALUAB Nephrology Research at CH19· Birmingham, ALKaiser Permanente Los Angeles Medical Center· Los Angeles, CAUCSF Clinical Research Center at Parnassus· San Francisco, CANephrology & Hypertension Associates, PC· Middlebury, CTYale University - Yale Nephrology Clinical Research Clinic· New Haven, CT

Related Studies