Di-PKD: A Pilot Trial of Dietary Intervention in Patients With Autosomal Dominant Polycystic Kidney Disease

Part of paid clinical trials in Loma Linda, California.

Sponsor
Loma Linda University
Study ID
NCT06786260
Status
Not Yet Recruiting

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Conditions

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Interventional Diet — OTHER
    Low salt, limited caffeine, high potassium, low phosphate, and limited protein and carbohydrate intake along with adequate water intake diet

Study Details

The goal of this interventional study is to evaluate the impact of a specific diet (low salt, limited caffeine, high potassium, low phosphate, limited protein, limited carbohydrate intake, adequate water intake) on changes in serum and urinary biomarkers, total kidney volume (TKV), and cyst progression in subjects with autosomal dominant polycystic kidney disease (ADPKD). Researchers will compare the results of subjects in the study diet (interventional) arm to the results of subjects in the regular diet (control) arm.

Key Dates

Start date
May 31, 2026
Status verified
Jan 2026
Primary completion
Dec 31, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Interventional Diet
    Subjects will follow a specified diet (low salt, limited caffeine, high potassium, low phosphate, and limited protein and carbohydrate intake along with adequate water intake) after 1 week of preconditioning for 12 months.
  • No Intervention: Regular Diet
    Subjects will follow the diet they normally adhere to after 1 week of preconditioning.

Primary Outcome Measure

Progression of kidney cysts by change in total kidney volume (TKV) from baseline to 12 months [ Time Frame: Change between baseline and 12 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Loma Linda University HealthLoma LindaCalifornia92354
Amir Abdipour, MD
909-202-0252

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By research site
Loma Linda University Health· Loma Linda, CA

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