Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures

Part of paid clinical trials in Orange, California.

Sponsor
University of California, Irvine
Study ID
NCT07145346
Phase
PHASE4
Status
Enrolling By Invitation

Conditions

  • Rib Fractures

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Suzetrigine (SUZ) — DRUG
    The intervention arm will receive oral suzetrigine (100 mg loading dose followed by 50 mg every 12 hours).
  • Placebo — DRUG
    The control arm will receive placebo capsules matched to suzetrigine for oral administration.

Study Details

Rib fractures cause a significant amount of pain and are associated with an increased risk of lung infections, long hospitalization, and increased cost. Effective pain control is the cornerstone of management to improve lung function and minimize complications. Most often this is done with a multimodal pain routine consisting of: acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), topical lidocaine, muscle relaxants, and opioids. However, suzetrigine is a promising alternative to treat acute pain associated with rib fractures. We think the addition of suzetrigine to a multimodal pain regimen will improve pain and decrease opioid use.

Key Dates

Start date
Nov 13, 2025
Status verified
Dec 2025
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Suzetrigine arm
    The intervention arm will receive oral suzetrigine (100 mg loading dose followed by 50 mg every 12 hours).
  • Placebo Comparator: Control arm
    The control arm will receive placebo capsules matched to suzetrigine for oral administration.

Primary Outcome Measure

Evaluation of Pain [ Time Frame: Through study completion of index hospitalization (up to 2 years) ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, IrvineOrangeCalifornia92868-

Find similar trials in Orange, CA

By research site
University of California, Irvine· Orange, CA

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