Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures

Part of paid clinical trials in Loma Linda, California.

Sponsor
Loma Linda University
Study ID
NCT06533904
Status
Not Yet Recruiting

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Conditions

  • Chest Wall Disorder
  • Pain, Chest
  • Respiratory Distress Syndrome
  • Respiratory Failure
  • Respiratory Insufficiency
  • Rib Fracture Multiple
  • Rib Fractures
  • Rib Trauma
  • Trauma

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Percutaneous Cryoablation of Intercostal Nerves — PROCEDURE
    Percutaneous Cryoablation of Intercostal Nerves
  • Multi-modal pain regimen — OTHER
    Standard rib fracture protocol including cyclooxygenase inhibitors, anti-neuropathic, muscle relaxers, short term anesthesia interventions (percutaneous block, epidural)

Study Details

The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes. The main questions it aims to answer are: Does percutaneous cryoablation improve short and long term pain scores? Does percutaneous cryoablation improve short and long term respiratory mechanics? Does percutaneous cryoablation improve long term quality of life? Does percutaneous cryoablation decrease delirium? Researchers will compare cryoablation to standard multimodal pain therapy to see if this impacts respiratory recovery. Participants will undergo randomization, percutaneous cryoablative procedure, and participate in tests at pre-determined intervals to evaluate their pulmonary recovery.

Key Dates

Start date
Sep 30, 2026
Status verified
Feb 2026
Primary completion
Jul 31, 2028
Completion
Jul 31, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Standard multi-modal pain regimen alone
  • Experimental: Standard multi-modal pain regimen with percutaneous cryoablation

Primary Outcome Measure

Pain Score: Numeric Pain Scale [ Time Frame: Through study completion, up to 1 year ]

Locations (1)

FacilityCityStateZIPSite coordinators
Loma Linda University HealthLoma LindaCalifornia92354
Martin G Rosenthal, MD
[email protected]
909-558-4286
Matthew E Reeves, MD
[email protected]
909-558-4289

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Loma Linda University Health· Loma Linda, CA

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