Distribution of Ventilation, Respiratory Drive and Gas Exchange: Measurements and Monitoring

Part of paid clinical trials in La Jolla, California.

Sponsor
University of California, San Diego
Study ID
NCT05462600
Status
Enrolling By Invitation

Conditions

  • OSA
  • Pulmonary Disease
  • Respiratory Failure
  • Respiratory System Abnormalities

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Position change — OTHER
    Distribution of ventilation, respiratory drive, pulmonary mechanics and gas exchange will be measured in 3 unique positions: prone, head of bed (HOB) flat (i.e. 0 degrees) and HOB elevated (i.e. 30 degrees).

Study Details

Respiratory physiology involves a complex interplay of elements including control of breathing, respiratory drive, pulmonary mechanics, distribution of ventilation and gas exchange. Body position may also play an important role in respiratory mechanics. While effective methods exist for measuring these variables, they are typically measured in isolation rather than in combination. In pulmonary disease, decreasing mechanical stress and strain and optimizing transpulmonary pressure or the distending pressure across the lung, minimizing overdistention and collapse are central to clinical management. Obesity has a significant impact on pulmonary mechanics and is a risk factor for obstructive sleep apnea (OSA). However, our understanding of these elements is limited even in the general population. The investigators plan to use various validated methods to assess control of breathing, respiratory drive, distribution of ventilation and gas exchange to obtain a better understanding of underlying physiologic signatures in patients with and without obesity and the role of posture/position, with a secondary analysis comparing participants with and without obstructive sleep apnea.

Key Dates

Start date
Jul 19, 2022
Status verified
Jun 2024
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: BMI>24.9 kg/m2
  • Arm: BMI 18-24.9 kg/m2

Primary Outcome Measure

Distribution of ventilation [ Time Frame: 3 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of California San Diego HealthLa JollaCalifornia92037-

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