Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
National Institute on Aging (NIA)
Study ID
NCT07099053
Status
Recruiting
Apply to this trial

Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
55 Years - 110 Years
Healthy Volunteers
Accepted

Study Details

Background: Some people experience cognitive decline as they age. That is, they lose memory, problem-solving, and other mental abilities. Amyloids are groups of proteins that develop in the brain and increase in number as people age. Researchers want to use imaging scans to track amyloids in people s brains over time. Their goal is to find out if any changes are related to cognitive decline or other medical issues. Objective: To learn how amyloids may affect brain structure and function as people age. Eligibility: People aged 55 years and older who are enrolled in the Baltimore Longitudinal Study of Aging. Design: Participants will have imaging scans and other tests every 1 to 4 years, depending on their age. Those 80 and older will be scanned yearly. These scans will be done during regular BLSA visits. The scans will be positron emission tomography and computed tomography (PET CT). Participants will be given fluid through a tube inserted into a vein in their arm. The fluid is a tracer that will cause the amyloids to light up in the images. Then they will lie on a bed with their head inside a PET CT scanner. They will lie still for about 30 minutes. Participants will have tests to assess their memory and other mental skills. They will answer questions about their mood and daily life. These tests will take about 40 minutes to complete; they may be done in person or by phone. Participants will give a contact number for someone who can answer questions about the participant s daily routine. These questions may be answered in person or by phone. Participants will be in this study for 5 years.

Key Dates

Start date
Jun 16, 2026
Status verified
Mar 2026
Primary completion
Dec 12, 2029
Completion
Dec 12, 2029

Study Design

Enrollment
400 participants (estimated)

Arms

  • Arm: Adults aged 55 and older.
    Adults aged 55 and older.

Primary Outcome Measure

Amyloid accumulation [ Time Frame: longitudinal ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institute of Aging, Clinical Research UnitBaltimoreMaryland21224
Luigi Ferrucci, M.D.
[email protected]
410-558-8110

Find similar trials in Baltimore, MD

By research site
National Institute of Aging, Clinical Research Unit· Baltimore, MD

Related Studies