Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

Part of paid clinical trials in Bishop, California.

Sponsor
McMaster University
Study ID
NCT07063732
Status
Recruiting
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Conditions

  • Exercise
  • High Altitude Hypoxia

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Ketone Monoester (KME) — DIETARY_SUPPLEMENT
    0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
  • Placebo — DIETARY_SUPPLEMENT
    Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement

Study Details

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Key Dates

Start date
May 28, 2025
Status verified
Jul 2025
Primary completion
Aug 31, 2025
Completion
Aug 31, 2025

Study Design

Enrollment
14 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: High Altitude (3800m; Barcroft Research Station)
    High altitude setting
  • Experimental: Low Altitude (334m; University of Guelph)
    Low altitude setting

Primary Outcome Measure

Cerebral Blood Velocity [ Time Frame: 3 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
Barcroft Research StationBishopCalifornia93514
Jeremy Walsh, PhD
[email protected]
9055259140

Find similar trials in Bishop, CA

By research site
Barcroft Research Station· Bishop, CA

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