Developing a Nutritional Supplement to Increase Collagen Synthesis in People

Part of paid clinical trials in Davis, California.

Sponsor
University of California, Davis
Study ID
NCT06138106
Status
Recruiting
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Conditions

  • Connective Tissue
  • Dietary Supplements
  • Exercise

Eligibility Criteria

Sex
ALL
Age
18 Years - 30 Years
Healthy Volunteers
Accepted

Interventions

  • Natural Product Supplement — DIETARY_SUPPLEMENT
    Participants will have blood drawn before and one hour after consuming the natural product supplement. For 7-days the participants will perform load-bearing exercise and consume the supplement. On the final day, blood will be collected 4 hours after the final exercise bout.
  • Placebo control — DIETARY_SUPPLEMENT
    Participants will have blood drawn before and one hour after consuming the placebo supplement. For 7-days the participants will perform load-bearing exercise and consume the supplement. On the final day, blood will be collected 4 hours after the final exercise bout.

Study Details

The purpose of this study is to test whether a natural product supplement can potentiate the increase in collagen synthesis following the ingestion of collagen protein. The investigators have developed a model of natural (GRAS certified) products that stimulate collagen synthesis, in vitro. The investigators will determine whether the natural product supplement can potentiate the collagen synthetic response to the ingestion of collagen protein. Basal and fed serum will be isolated and these samples will be used to treat human engineered ligaments.

Key Dates

Start date
Nov 21, 2023
Status verified
Jan 2026
Primary completion
Jun 1, 2026
Completion
Jun 1, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Natural Product Supplement
    The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg), epicatechin (75 mg), vitamin E (350 iU) and stevia extract (225 mg).
  • Placebo Comparator: Placebo
    The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg) and sweetener.

Primary Outcome Measure

Collagen protein synthesis [ Time Frame: 7 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Hickey LaboratoryDavisCalifornia95616
Kevin Paulussen, PhD
[email protected]
Keith Baar, PhD
[email protected]

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Hickey Laboratory· Davis, CA

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