Stress Trajectories and Anhedonia in Adolescence Research Study

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT07040449
Status
Recruiting
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Conditions

  • Adolescent Development
  • Anhedonia
  • Stress Response

Eligibility Criteria

Sex
ALL
Age
13 Years - 15 Years
Healthy Volunteers
Accepted

Interventions

  • Montreal Imaging Stress Task — BEHAVIORAL
    Psychosocial stress procedure consisting of completing sections of mental arithmetic that are 5.5 minutes in length, during which the individual receives neutral and negative evaluative feedback about their performance relative to their peers.
  • Trier Social Stress Test for Children — BEHAVIORAL
    Psychosocial stress procedure in which the individual tells a story for 5 minutes in front of two neutral judges and performs mental arithmetic in front of the judges for 5 minutes.

Study Details

This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of activity in the brain and body that adolescents may have in response to stress. The main question this study aims to answer is whether different patterns of activity in the brain and body are related to whether adolescents develop anhedonia and how high or low levels of anhedonia are over time. This study will enroll 192 adolescents who are between 13 and 15 years. Adolescents will complete tasks three times: at the beginning of the study, 10 months after that, and then 10 months after that. In total, they will be part of the study for 20 months. At each time, adolescents will complete surveys, provide samples of spit to measure hormones and provide pictures of their brain to measure brain activity, participate in mildly stressful tasks, and complete different activities that measure how they think. The investigators will also ask each adolescent's parent or legal guardian to answer some surveys about themselves and their child.

Key Dates

Start date
Mar 12, 2025
Status verified
Jun 2025
Primary completion
Feb 28, 2030
Completion
Feb 28, 2030

Study Design

Enrollment
192 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Adolescent Teenagers
    Participants aged 13-15 (approximately Tanner pubertal stage 2-4) at study entry.

Primary Outcome Measure

Anhedonia as assessed by the SHAPS [ Time Frame: Baseline, 10-months, 20-months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of North Carolina at Chapel HillChapel HillNorth Carolina27599
Clinical Research Coordinator
[email protected]
919-966-2927

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By research site
University of North Carolina at Chapel Hill· Chapel Hill, NC

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