Adverse Adolescent Pathways to Substance Use

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT06977178
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
12 Years - 14 Years
Healthy Volunteers
Accepted

Interventions

  • Trier Social Stress Test — BEHAVIORAL
    Psychosocial stress procedure; 5 minutes of public speaking (preceded by 5 minutes of preparation) and 5 minutes of mental arithmetic.

Study Details

Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use (APSU). Participants: Children (N=200) aged 12-14 with symptoms of anxiety and their legal caregiver will be recruited from clinical and community sources. Procedures: Youth participants will complete several questionnaires and interviews, undergo neuroimaging while performing cognitive tasks, and have their heart rate and skin conductance monitored during a mildly stressful task. Caregivers will complete several questionnaires.

Key Dates

Start date
Feb 20, 2024
Status verified
May 2025
Primary completion
Jun 30, 2029
Completion
Jun 30, 2030

Study Design

Enrollment
180 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Trier Social Stress Test (TSST)
    The Trier Social Stress Test for Children (TSST-C) is a social stressor involving story telling in front of two neutral judges, preparation time and a cognitive stressor involving mental arithmetic-counting backward from 1023 by 13s. It is used to elicit physiological stress responses. The TSST-C is administered in 4 parts: an anticipatory stress phase (5 min to prepare the speech); the speech task (5 min), the arithmetic task (5 min), and the recovery phase (up through 40 min post-task).

Primary Outcome Measure

Reaction time during the functional magnetic resonance imaging (FMRI) Stop Signal Task [ Time Frame: baseline, 12-months, 24-months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of North Carolina at Chapel Hill School of MedicineChapel HillNorth Carolina27599
Aysenil Belger, PhD
[email protected]
Aysenil Belger, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Chapel Hill, NC

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
The University of North Carolina at Chapel Hill School of Medicine· Chapel Hill, NC

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