Can You Breathe Your Way To Better Health?

Part of paid clinical trials in Greeley, Colorado.

Sponsor
University of Northern Colorado
Study ID
NCT06829836
Status
Enrolling By Invitation

Conditions

  • Autonomic Dysfunction
  • Cancer
  • Chronic Stress

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Hight intensity interval training — BEHAVIORAL
    Participants assigned to this intervention group will complete 6 supervised HIIT sessions over 2 weeks.
  • Cyclic Hyperventilation with Retention — BEHAVIORAL
    Participants of this intervention group will complete a total of 10 remote guided breathing sessions on Zoom over 2 weeks.

Study Details

The purpose of this clinical trial is to explore the effects of either a 2-week high-intensity interval training (HIIT) or breath training intervention on measures of overall health, circulating biomarkers of stress, and immune function. Specific aims include: - Does a 2-week HIIT or breath training intervention improve measurements of overall health, including heart rate variability, physical activity, sleep quality, and severity of depression, anxiety, and stress? -Does a 2-week HIIT or breath training intervention improve circulating concentrations of stress-related biomarkers? Does a 2-week HIIT or breath training intervention improve immune function? Researchers will compare HIIT and breath training to see if equivalent immune improvements are observed. Participants will: -Undergo 2 weeks of HIIT or breath training interventions at a frequency of 3 times per week for 30 minutes or 5 times per week for 5 minutes if placed into an intervention group. -Undergo testing measures at the two pre- and post-intervention time points, if placed in the intervention groups or the healthy control group.

Key Dates

Start date
Jan 27, 2025
Status verified
Jan 2025
Primary completion
May 1, 2025
Completion
Jun 1, 2025

Study Design

Enrollment
36 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • No Intervention: CON, control
    The control group will undergo the same testing procedures outlined above, but they will be asked to maintain their current level of activity and normal daily habits for the duration of the intervention.
  • Active Comparator: HIG, High intensity group
    During the exercise session, HR will be measured via a Polar heart rate strap (Kempele, Finland). The training sessions will consist of six 90-second high-intensity cycling (HIC) sprints performed on a cycle ergometer (Monark Ergomedic 895E, Monark, Varberg, Sweden) at 80-90% VO2max, followed by 180 seconds of low-intensity cycling (LIC) at 50-60% of VO2max. During both HIC and LIC intensities, participants will be asked rate of perceived exertion, which will be compared to the participants' heart rate throughout the exercise sessions. This supervised training protocol will require 9 minutes of HIC at 80-90% VO2max and 18 minutes of LIC at 50-60% VO2max. The cycling session will begin with a brief warm-up and end with a cool-down down totaling the entire supervised exercise session for 30 minutes. Training sessions will be performed 48 hours after the previous training session for a total of 3 times per week on Mondays, Wednesdays, and Fridays.
  • Active Comparator: CHG, Cyclic hyperventilation group
    The breathing intervention will consist of a daily breathing practice lasting 5 to 10 minutes for 5 days per week. Breathing practice is a form of cyclic hyperventilation consisting of 30 breath (inhalation and exhalation) repetitions followed by an exhaled breath retention for 15 seconds during the first week and up to 30 seconds during the second week. A total of 3 rounds will be performed by the participants. Participants will be instructed to perform breathing repetitions in a controlled and consistent manner while either seated or lying down. Participants will receive guided instruction via a video on breath cycle queues, informing the participants when to inhale, exhale, and when to retain their breath while being supervised by the research team via Zoom call. Upon completion of the breath training sessions, the research team will conduct a guided cooldown and check in with all participants to ensure they are feeling no adverse side effects from the breathing exercise.

Primary Outcome Measure

Serum Analysis: C-reactive protein (CRP) [ Time Frame: Visit 1(Week 1) and Visit 3 (Week 4): 15 minutes for blood draw. The assay itself takes 3 hours. ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Northern Colorado, 1610 Gunter Hall, 1828 10th Ave, Greeley, CO 80631GreeleyColorado80631-

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By research site
University of Northern Colorado, 1610 Gunter Hall, 1828 10th Ave, Greeley, CO 80631· Greeley, CO

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