Childhood Cancer Survivor Study

Conditions

• Cancer

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Accepted

Study Details

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

Key Dates

Start date

Jan 5, 1995

Status verified

Apr 2026

Primary completion

Nov 30, 2026

Completion

Nov 30, 2026

Study Design

Enrollment

50,000 participants (estimated)

Arms

• Arm: Cancer survivors
  Survivors of cancer, diagnosed under 21 years of age, between 1970 and 1999 This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, for an increased risk of late-occurring events associated with excess mortality and morbidity.
• Arm: Sibling Controls
  A group of sibling controls will be identified to provide: (1) the ability to make direct comparisons with the survivors, (2) data on outcomes in a non-cancer population, and (3) additional comparison group to determine consistency of findings between data sources.

Primary Outcome Measure

To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors. [ Time Frame: 25 years ]

Central Contacts

• Gregory T. Armstrong, MD, MSCE
  888-226-4343
  [email protected]

Locations (30)

Find similar trials in Birmingham, AL

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