Childhood-Onset Essential Hypertension Natural History Study

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Human Genome Research Institute (NHGRI)
Study ID
NCT06778239
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
2 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

Background: Childhood-onset essential hypertension (COEH) is high blood pressure that develops in children and teens. High blood pressure is a major risk factor for heart disease. COEH is more likely to be caused by changes in genes rather than by factors like stress or diet. Researchers want to learn more about how changes in genes relate to COEH. They hope to use that information to develop better treatments for children with high blood pressure. Objective: This natural history study will look for genes and gene changes that may lead to COEH. Eligibility: People aged 2 years and older with COEH or who had COEH when they were children. Healthy relatives of those with COEH are also needed. Design: Participants will have one clinic visit per year for up to 10 years. All participants will have a physical exam. They will provide samples of blood and urine. At their first visit, they will have a swab (like a Q-tip) rubbed between their gums and cheeks. They may agree to having a skin biopsy; a piece of skin about the size of a pencil eraser will be removed. Affected participants aged 2 to 17 years old will have additional tests: * They will have sensors placed on their skin to look at their blood vessels and see how blood is moving in their bodies. * They will lie or stand while a machine measures the amount of fat and muscle in their bodies. * They will have an ultrasound; a wand will be rubbed against their skin to take pictures of their kidneys. Other things are optional for all participants: * They may have photographs taken of their bodies. * They may have tests of their heart function. * They may have different types of imaging scans....

Key Dates

Start date
May 30, 2025
Status verified
May 2026
Primary completion
Dec 9, 2034
Completion
Dec 9, 2034

Study Design

Enrollment
2,300 participants (estimated)

Arms

  • Arm: Affected
    Study participants that are 2-17 years old and have COEH or participants that are 18+ years old that were diagnosed with COEH when they were children.
  • Arm: Unaffected
    Study participants that are 2+ years old and have never been diagnosed with COEH.

Primary Outcome Measure

Find all genes that cause COEH. [ Time Frame: 10 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
NIH Clinical Center Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

Find similar trials in Bethesda, MD

By condition
Hypertension (high blood pressure)
By specialty
CardiologyHeart disease
By research site
National Institutes of Health Clinical Center· Bethesda, MD

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