Brain Volume and Cardiac Function in Heart Failure

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT06623344
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Magnetic Resonance Imaging with or without Contrast — OTHER
    Completion of Magnetic Resonance Imaging of the brain, heart, lungs, and liver with and without contrast.

Study Details

Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population. Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients. Reduction of cerebral blood flow has been suggested as the pathophysiological pathway linking HF and structural brain changes. Indeed, lower cardiac index levels were related to lower cerebral blood flow in older adults without stroke, dementia, or heart failure. A few prior studies have examined the subcortical structural differences in patients with HF compared to controls. Brain volume loss (including putamen and hippocampal volumes) have been reported in patients with low ejection fraction. Significant gray matter loss was found in specific brain regions of HF patients and included structures that serve demonstrated roles in cognitive functions. In the investigator's previous study (Comprehensive Imaging Exam of Convalesced COVID-19 Patients - COVID-19 RELATED SUBMISSION-IRB00252436), involving 100 participants (volunteers with normal heart function (ejection fraction; 50%)), the investigators observed significant correlations between thalamic volumes and ventricular stroke volumes in volunteers. Building on these findings, the investigators intend to expand the research to include individuals with heart failure (HF), employing the same MRI protocol. The study will involve obtaining a set of T1-weighted brain images to measure the volumes of seven subcortical structures. The investigators goal is to explore the relationship between subcortical volumes and cardiac parameters. Additionally, the investigators will examine whether patients with HF experience a more rapid reduction in subcortical volumes compared to those with normal cardiac function (EF;50%).

Key Dates

Start date
Nov 10, 2024
Status verified
Apr 2026
Primary completion
Oct 1, 2026
Completion
Oct 1, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Other: Hospitalized
    Participants who were hospitalized due to heart failure (HF) illness.
  • Other: Non-Hospitalized
    Participants who had heart failure (HF) but did not require hospitalization secondary to the illness.

Primary Outcome Measure

Subcortical Volumes in Heart Failure [ Time Frame: From enrollment up to 30 days post treatment ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Johns Hopkins Center for Advanced Imaging and Research Science, Johns Hopkins Science + Technology Park at 1812 Ashland Avenue, Baltimore, MDBaltimoreMaryland21287
Joao AC Lima, MD
[email protected]
410-614-1284
Jason Ortman
[email protected]
Joao AC Lima, MD (PRINCIPAL_INVESTIGATOR)
Johns Hopkins HospitalBaltimoreMaryland21287
Jason Ortman, Research Imaging Technologist
[email protected]
4106141284

Find similar trials in Baltimore, MD

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
Johns Hopkins Center for Advanced Imaging and Research Science, Johns Hopkins Science + Technology Park at 1812 Ashland Avenue, Baltimore, MD· Baltimore, MDJohns Hopkins Hospital· Baltimore, MD

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