Effect of Cannabis on E-Cigarette Use Behavior

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT06609109
Phase
PHASE1
Status
Recruiting
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Conditions

  • Cannabis Use
  • Electronic Cigarette Use
  • Tobacco Use

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • THC High Dose — DRUG
    Low dose of THC (30 mg)
  • THC Low Dose — DRUG
    Low dose of THC (5 mg)
  • THC 0mg — DRUG
    Placebo dose of THC (0 mg)
  • E-Cigarette Full Nicotine — DRUG
    E-Cigarette with Nicotine
  • E-Cigarette Placebo Nicotine — DRUG
    E-Cigarette with No Nicotine

Study Details

The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes. The study's goals are to test demand for e-cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke e-cigarettes and either smoke or vape THC in the laboratory.

Key Dates

Start date
Mar 19, 2025
Status verified
Apr 2026
Primary completion
Apr 1, 2029
Completion
Oct 1, 2029

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Smoked THC
    Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive e-cigarette containing 0% and 5.0% nicotine.
  • Experimental: Vaporized THC
    Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive e-cigarette containing 0% and 5.0% nicotine.

Primary Outcome Measure

Demand Elasticity [ Time Frame: 45 minutes after THC or placebo administration ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins University Behavioral Pharmacology Research UnitBaltimoreMaryland21224
Dustin Lee, PhD
[email protected]
410-550-4035
Lauren Morris, MHS
[email protected]
410-550-6953
Dustin Lee, PhD (PRINCIPAL_INVESTIGATOR)

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