Effect of Cannabis on Cigarette Use Behavior

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT06609083
Phase
PHASE1
Status
Recruiting
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Conditions

  • Cannabis Use
  • Cigarette Smoking
  • Tobacco Use

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • THC 30mg — DRUG
    High dose of THC (30 mg)
  • THC 5mg — DRUG
    Low dose of THC (5 mg)
  • THC 0mg — DRUG
    Placebo dose of THC (0 mg)
  • Cigarette Full Nicotine — DRUG
    Full nicotine cigarette
  • Cigarette Reduced Nicotine — DRUG
    Reduced nicotine cigarette

Study Details

The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.

Key Dates

Start date
Jan 22, 2025
Status verified
Jan 2026
Primary completion
Apr 1, 2029
Completion
Oct 1, 2029

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Smoked THC
    Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive combustible cigarettes containing 0.03mg and 0.80mg of nicotine.
  • Experimental: Vaporized THC
    Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive combustible cigarettes containing 0.03mg and 0.80mg of nicotine.

Primary Outcome Measure

Demand Intensity [ Time Frame: 45 minutes after THC or placebo administration ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins University Behavioral Pharmacology Research UnitBaltimoreMaryland21224
Dustin Lee, PhD
[email protected]
410-550-4035
Lauren Morris, MHS
[email protected]
410-550-6953
Dustin Lee, PhD (PRINCIPAL_INVESTIGATOR)

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