Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Georgia State University
Study ID
NCT06608680
Status
Recruiting
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Conditions

  • Control Subjects
  • Language
  • Reading

Eligibility Criteria

Sex
ALL
Age
18 Years - 30 Years
Healthy Volunteers
Accepted

Interventions

  • iTBS — BEHAVIORAL
    Excitatory stimulation of supramarginal gyrus
  • cTBS — BEHAVIORAL
    Inhibitory stimulation to supramarginal gyrus
  • Sham Stimulation — BEHAVIORAL
    Sham stimulation of supramarginal gyrus

Study Details

The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are: 1. At what point after stimulation are the greatest effects on behavior seen 2. How excitatory and inhibitory stimulation affect behavior Researchers will compare stimulation types against a sham condition to see effects on reading and language behavior. Participants will be asked to * undergo reading, language, and cognitive testing * receive an MRI * receive TMS stimulation * perform language, reading, and motor tasks

Key Dates

Start date
May 1, 2023
Status verified
Sep 2024
Primary completion
Dec 31, 2027
Completion
Dec 31, 2028

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: iTBS/Sham
    Adults age 18-30 with typical reading and language abilities
  • Experimental: cTBS/Sham
    Adults age 18-30 with typical reading and language abilities

Primary Outcome Measure

Phonological Decoding Reaction Time [ Time Frame: Four time points after each stimulation (20, 40, 60 and 80 minutes after stimulation) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Georgia State UniversityAtlantaGeorgia30303
Rachael Harrington, Ph.D. CCC-SLP
[email protected]
404-413-6219
C. Nikki Arrington, Ph.D.
[email protected]
404-385-8621
Rachael Harrington, Ph.D. CCC-SLP (PRINCIPAL_INVESTIGATOR)

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