Adding Polyphenol-rich Pulses to Daily Diet Improves Skin Health by Reshaping the Skin Microbiome

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT06538415
Status
Recruiting
Apply to this trial

Conditions

  • Healthy

Eligibility Criteria

Sex
FEMALE
Age
45 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Pulse Diet — OTHER
    Participants will consume cooked pulses on an alternating basis over the 10-week intervention period. The pulses consist of 455 grams of the tri-bean blend (kidney, pinto, black bean), equivalent to 350 calories, and 225 grams of black lentils (400 calories).
  • Control Rice Diet — OTHER
    Participants will consume cooked white rice (375 calories) over 10 weeks

Study Details

Skin health is influenced by the microbiome, lipids, oxidative stress, inflammation, and UV exposure. A 12-week trial with 48 women aged 45-65 will test if polyphenol-rich pulses improve skin health by affecting these factors. Using a white rice control diet, the study will measure skin parameters and analyze correlations with changes in lipids and microbiome, potentially proving the benefits of pulses.

Key Dates

Start date
Apr 24, 2026
Status verified
Jun 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Pulse Diet
    Participants will consume cooked pulses on an alternating basis over the 10-week intervention period. The pulses consist of 455 grams of the tri-bean blend (kidney, pinto, black bean), equivalent to 350 calories, and 225 grams of black lentils (400 calories).
  • Active Comparator: Control Rice Diet
    Participants will consume cooked white rice (375 calories) over 10 weeks

Primary Outcome Measure

Skin sensitivity after UV radiation [ Time Frame: 84 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Food Science and Human NutritionGainesvilleFlorida32608
Liwei Gu, phd
[email protected]
352-294-3730

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By research site
Food Science and Human Nutrition· Gainesville, FL

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