Exercise, Brain Activity, and Weight Maintenance

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Joslin Diabetes Center
Study ID
NCT06511310
Status
Recruiting
Apply to this trial

Conditions

  • Appetitive Behavior
  • Bariatric Surgery Candidate
  • Obesity
  • Weight Gain

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise — OTHER
    High Intensity Exercise

Study Details

This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.

Key Dates

Start date
Sep 15, 2025
Status verified
Aug 2025
Primary completion
Jul 1, 2026
Completion
Jul 1, 2027

Study Design

Enrollment
15 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Exercise Training
    Subjects will complete a supervised high-intensity interval training program for 12 weeks, including four weekly training sessions. The training session will include a 3 minute warm-up followed by six 40 second bouts of high intensity (85-95% of VO2peak) with 3 minutes moderate intensity (45-55% of VO2peak) between each bout of high intensity, concluding with a 3 minute cool-down. Each participant's target heart rate will be specific to them, calculated from the exercise test completed during Visit 1.

Primary Outcome Measure

Changes in connectivity between brain areas following exercise training by using resting state functional MRI. [ Time Frame: Evaluation of changes in brain function by fMRI before and after 12 weeks of exercise training. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Joslin Diabetes CenterBostonMassachusetts02215
Simpson
[email protected]
617-735-3924

Find similar trials in Boston, MA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Joslin Diabetes Center· Boston, MA

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