Effects of Levetiracetam Monotherapy on Various Hematological Parameters in Adult Patients Suffering of Epilepsy

Sponsor
Assiut University
Study ID
NCT06491303
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Accepted

Study Details

Low therapeutic index of established antiepileptic drugs (AEDs) coupled with better understanding of the pathophysiology of seizure has encouraged the development of several novel AEDs. The conventional antiepileptics like phenytoin, phenobarbitone, valproate and carbamazepine and newer antiepileptics like levetiracetam. are used for epilepsy. AEDs induce potentially toxic effects over a period of time which remains undetermined over very long time. Earlier studies in this regard, states uneven results about hematological (Hb%, blood cell count etc.) toxicity of AEDs.

Key Dates

Start date
Nov 1, 2024
Status verified
Jun 2024
Primary completion
Nov 1, 2025
Completion
Dec 1, 2025

Study Design

Enrollment
45 participants (estimated)

Arms

  • Arm: Distribution of studied patients by age in years.
    Adult patients suffering of epilepsy aged 18 to 60 years old
  • Arm: Distribution of studied patients by duration of levetiracetam administration in months
    Adult patients suffering of epilepsy and receiving treatment of levetiracetam for at least 6 months

Primary Outcome Measure

Study of Effects of Levetiracetam Monotherapy on Various Hematological Parameters in Adult Patients Suffering of Epilepsy [ Time Frame: one years ]

Central Contacts

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