Monetary Incentive Delay Task for Probing Reward-related Neural Processes

Part of paid clinical trials in Stony Brook, New York.

Sponsor
Stony Brook University
Study ID
NCT06369623
Status
Recruiting
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Conditions

  • Adolescent Development

Eligibility Criteria

Sex
ALL
Age
14 Years - 17 Years
Healthy Volunteers
Accepted

Interventions

  • Monetary Incentive Delay Task — OTHER
    The Monetary Incentive Delay functional Magnetic Resonance Imaging task is well-characterized and commonly utilized in research settings to measure neural activation between win and loss conditions, as well as between phases of anticipation and consummation/outcome. A recent meta-analysis indicates that the task has been used in over 80 studies and 5,000 subjects as of Year 2022. The task is also valid and appropriate for use in children and adolescents, as demonstrated by its inclusion in National Institute on Drug Abuse ABCD study. The task is utilized for its short-lived, reversible, and/or benign effects on brain activation (e.g., brief processing of a reward cue).

Study Details

150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.

Key Dates

Start date
Apr 6, 2024
Status verified
May 2025
Primary completion
Nov 30, 2028
Completion
Nov 30, 2028

Study Design

Enrollment
300 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Whole sample
    All enrolled subjects will complete a standard Monetary Incentive Delay Task if able. Inclusion of this task meets criteria for Basic Experimental Studies Involving Humans (BESH)

Primary Outcome Measure

Amount of Brain Activation (BOLD Signal) during Monetary Incentive Delay Task by Condition [ Time Frame: Baseline, 18-month, 36-month. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stony Brook MedicineStony BrookNew York11794
Greg Perlman, PhD
[email protected]
631-638-1922
Roman Kotov, PhD
Greg Perlman, PhD (PRINCIPAL_INVESTIGATOR)

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Stony Brook Medicine· Stony Brook, NY

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