Modulating Reward Learning Using Transcranial Magnetic Stimulation

Part of paid clinical trials in Newark, New Jersey.

Sponsor
Rutgers, The State University of New Jersey
Study ID
NCT06323057
Status
Recruiting
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Conditions

  • Behavior

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Single pulse TMS to the frontal cortex — DEVICE
    Single pulse TMS will be delivered to the left frontal cortex, and stimulation intensity will be at 110% of resting motor threshold.

Study Details

Our specific aim is to examine the effects of TMS on reward processing during goal-directed behavior. In these experiments the investigators will utilize a scalp-recorded brain oscillation called frontal midline theta that is believed to index the sensitivity of the cingulate cortex to reward feedback. Here the investigators will asked whether this electrophysiological signal can be modulated up or down using TMS while participants engage in decision making tasks, and if so, whether it would affect the encoding of rewards and subsequent choices during task performance.

Key Dates

Start date
Feb 14, 2024
Status verified
Nov 2025
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
28 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Single-pulse Peak Phase TMS
    Participants will receive a single active TMS pulse during the peak phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target . For the second TMS session, participants will receive single pulse Sham TMS during the peak phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target. Total number of TMS pulse for each session is 520 pulses
  • Experimental: Single-pulse Trough Phase TMS
    Participants will receive a single active TMS pulse during the trough phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target . For the second TMS session, participants will receive single pulse Sham TMS during the peak phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target. Total number of TMS pulse for each session is 520 pulses

Primary Outcome Measure

Event-related Brain Oscillation: Frontal Midline Theta [ Time Frame: [Time Frame: Day 0 (day of testing)] ]

Locations (1)

FacilityCityStateZIPSite coordinators
Rutgers University - NewarkNewarkNew Jersey07102
Travis E Baker, PhD
[email protected]
862-250-3351
Daniel Robles, PhD
[email protected]
973-353-3509

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Rutgers University - Newark· Newark, NJ

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