Neural Mechanisms for Reducing Interference During Episodic Memory Formation

Part of paid clinical trials in Eugene, Oregon.

Sponsor
University of Oregon
Study ID
NCT05092100
Status
Enrolling By Invitation

Conditions

  • Behavior

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Visual stimulus similarity — BEHAVIORAL
    Visual stimulus similarity will be varied in order to test for effects on memory. Learning protocol (the order and frequency with which stimuli are learned) will also be varied.
  • fMRI — OTHER
    fMRI will be used to measure patterns of BOLD activity during learning.
  • Eye tracking — BEHAVIORAL
    Eye tracking will be used to measure patterns of eye movements when viewing images.

Study Details

Healthy individuals from the University of Oregon and surrounding community will be recruited for participation in behavioral, fMRI and eye tracking experiments that investigate human memory. Recruitment will involve emails, flyers, and local advertisements. Individuals between the ages of 18-80 (or 18-35 for some studies) will be eligible. The broad objective of the research is to understand how humans form distinct memories for similar experiences. Experimental sessions will involve studying and trying to remember various images (e.g., images of natural scenes). The intervention will involve manipulating the similarity and/or learning protocol for the studied images. Outcome measures will include (a) behavioral measures of memory, and/or (b) fMRI measures of hemodynamic activity, and/or (c) eye tracking measures of gaze direction. Experimental sessions will last approximately 1-3 hours.

Key Dates

Start date
Sep 29, 2021
Status verified
Sep 2024
Primary completion
Dec 31, 2025
Completion
Jan 31, 2026

Study Design

Enrollment
737 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Behavioral
    This arm will use behavioral procedures to test memory for different visual stimulus conditions.
  • Experimental: fMRI pattern similarity
    This arm will use fMRI and behavioral methods to test memory for different visual stimulus conditions.
  • Experimental: eye tracking
    This arm will use eye tracking and behavioral methods to test memory for different visual stimulus conditions.

Primary Outcome Measure

Behavior [ Time Frame: Data will be collected over a 5 year period. Results from sub-studies will be analyzed within 6 months of the conclusion of data collection. ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of OregonEugeneOregon97403-

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By research site
University of Oregon· Eugene, OR

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