Using TMS to Understand Neural Processes of Social Motivation

Conditions

• Major Depressive Disorder
• Social Anxiety Disorder
• Social Avoidant Behavior

Eligibility Criteria

Sex

ALL

Age

25 Years - 50 Years

Healthy Volunteers

Not accepted

Interventions

• TMS — DEVICE
  TMS will be administered using a Cool B-65 coil to a personalized right dlPFC region.

Study Details

The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks. Adults in the Auburn/Opelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.

Key Dates

Start date

Sep 30, 2025

Status verified

Feb 2026

Primary completion

Jul 31, 2029

Completion

Jul 31, 2029

Study Design

Enrollment

40 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: TMS A
  Active continuous thetaburst stimulation administered over right dorsolateral prefrontal cortex for 40 seconds (600 pulses total)
• Sham Comparator: TMS B
  Sham continuous thetaburst stimulation administered over right dorsolateral prefrontal cortex for 40 seconds (600 pulses total)

Primary Outcome Measure

Social motivation [ Time Frame: Immediately post-intervention ]

Locations (1)

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