Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT06263452
Phase
PHASE4
Status
Recruiting
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Conditions

  • Cardiovascular Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - 30 Years
Healthy Volunteers
Accepted

Interventions

  • Propranolol — DRUG
    Tablet encapsulated to visually look identical to the placebo.
  • Placebo — DRUG
    Encapsulated sugar pill to visually look identical to the experimental condition.

Study Details

The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.

Key Dates

Start date
May 1, 2024
Status verified
Oct 2025
Primary completion
May 31, 2026
Completion
May 31, 2026

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Propranolol
    Propranolol tablet, 40mg, one-time, orally
  • Placebo Comparator: Placebo
    Encapsulated placebo tablet

Primary Outcome Measure

Change in levels of pro-inflammatory cytokine interleukin-6 in response to social stress [ Time Frame: Post-drug baseline to 90-minutes post-stress task (T-90) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Social Neuroscience and Health LaboratoryChapel HillNorth Carolina27514
Keely A Muscatell, PhD
[email protected]
916-495-7661
Jessica R Cohen, PhD (SUB_INVESTIGATOR)
Kristen A Lindquist, PhD (SUB_INVESTIGATOR)
Zev Nakamura, MD (SUB_INVESTIGATOR)

Find similar trials in Chapel Hill, NC

By research site
Social Neuroscience and Health Laboratory· Chapel Hill, NC

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