Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT06260722
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose cotransporter-2 inhibitor (SGLT2i). The study will last about 26 months and may include up to 24 visits.

Key Dates

Start date
Feb 21, 2024
Status verified
Apr 2026
Primary completion
Aug 31, 2026
Completion
Jan 31, 2027

Study Design

Enrollment
1,250 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose Level 1
    Participants will receive retatrutide administered subcutaneously (SC).
  • Experimental: Retatrutide Dose Level 2
    Participants will receive retatrutide administered SC.
  • Active Comparator: Semaglutide
    Participants will receive semaglutide administered SC.

Primary Outcome Measure

Change from Baseline in Hemoglobin A1c (HbA1c) (%) [ Time Frame: Baseline, Week 80 ]

Locations (38)

FacilityCityStateZIPSite coordinators
University of Alabama - Department of Nutrition SciencesBirminghamAlabama35294-
Neighborhood Healthcare Institute of HealthEscondidoCalifornia92025-
Long Beach Research InstituteLong BeachCalifornia90805-
Valley Clinical Trials, Inc.NorthridgeCalifornia91325-
Rancho Cucamonga Clinical ResearchRancho CucamongaCalifornia91730-
University of Colorado Anschutz Medical CampusAuroraColorado80045-
Arrow Clinical TrialsDaytona BeachFlorida32117-
New Age Medical Research CorporationMiamiFlorida33186-
South Broward ResearchMiramarFlorida33027-
Clinical Research of Central FloridaWinter HavenFlorida33880-
Herman Clinical ResearchSuwaneeGeorgia30024-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Pacific Diabetes & Endocrine CenterHonoluluHawaii96817-
Rocky Mountain Clinical ResearchIdaho FallsIdaho83404-
Deaconess Clinic - Gateway Health CenterNewburghIndiana47630-
IMA Clinical Research Monroe - ArmandMonroeLouisiana71201-
MedStar Health Research Institute (MedStar Physician Based Research Network)HyattsvilleMaryland20782-
Brigham and Women's Hospital Diabetes ProgramBostonMassachusetts02115-
NECCR PrimaCare ResearchFall RiverMassachusetts02721-
Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroyMichigan48098-
Palm Research Center SunsetLas VegasNevada89148-
Palm Research Center TenayaLas VegasNevada89128-
NYC Research INCLong Island CityNew York11106-
Medication ManagementGreensboroNorth Carolina27405-
Remington Davis Clinical ResearchColumbusOhio43215-
Alliance for Multispecialty Research, LLCNormanOklahoma73069-
Central States ResearchTulsaOklahoma74136-
The Corvallis Clinic, P.C.CorvallisOregon97330-
Thomas Jefferson University HospitalPhiladelphiaPennsylvania19107-
Velocity Clinical Research, DallasDallasTexas75230-
Valley Institute of Research - Fort WorthFort WorthTexas76164-
Juno ResearchHoustonTexas77040-
Southern Endocrinology AssociatesMesquiteTexas75149-
Consano Clinical Research, LLCShavano ParkTexas78231-
Texas Valley Clinical ResearchWeslacoTexas78596-
Medrasa Clinical ResearchWylieTexas75098-
Central Washington Health Services Association d/b/a Confluence HealthWenatcheeWashington98801-
IMA Clinical Research West VirginiaMorgantownWest Virginia26505-

Find similar trials in Birmingham, AL

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Alabama - Department of Nutrition Sciences· Birmingham, ALNeighborhood Healthcare Institute of Health· Escondido, CALong Beach Research Institute· Long Beach, CAValley Clinical Trials, Inc.· Northridge, CARancho Cucamonga Clinical Research· Rancho Cucamonga, CAUniversity of Colorado Anschutz Medical Campus· Aurora, CO

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