Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff

Conditions

• Tobacco-Related Carcinoma

Eligibility Criteria

Sex

ALL

Age

21 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Biospecimen Collection — PROCEDURE
  Undergo blood sample collection
• Carbon Monoxide Measurement — PROCEDURE
  Undergo CO test
• Smokeless Tobacco Use — BEHAVIORAL
  Use moist snuff
• Survey Administration — OTHER
  Ancillary studies

Study Details

This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco \[SLT\]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.

Key Dates

Start date

Dec 20, 2024

Status verified

Dec 2025

Primary completion

Mar 1, 2027

Completion

Jan 31, 2028

Study Design

Enrollment

80 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Arms

• Placebo Comparator: Prevention (Smokeless tobacco use: Usual Brand)
  Participants use their usual brand of moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
• Active Comparator: Prevention (Smokeless tobacco use: Low FBN Long Cut)
  Participants use low FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
• Active Comparator: Prevention (Smokeless tobacco use: Low FBN Fine Cut)
  Participants use low FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
• Active Comparator: Prevention (Smokeless tobacco use: High FBN Long Cut)
  Participants use high FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
• Active Comparator: Prevention (Smokeless tobacco use: High FBN Fine Cut)
  Participants use high FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.

Primary Outcome Measure

Frequencies of flavors used by participants [ Time Frame: Up to 2 years ]

Central Contacts

• The Ohio State Comprehensive Cancer Center
  800-293-5066
  [email protected]

Locations (2)

Find similar trials in Columbus, OH

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