Fatty Acid Modulation of Brain Function in Older Adults

Part of paid clinical trials in Burlington, Vermont.

Sponsor
University of Vermont
Study ID
NCT06192407
Status
Recruiting
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Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
65 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • High Oleic Acid Diet — DIETARY_SUPPLEMENT
    Subjects are provided with all food for each meal every day. The food is low in fat. In addition, subjects are provided with an oil mix that is 100% hazelnut oil. They will be taught to consume the oil with each meal and mix it in with the food provided.
  • High Palmitic Acid Diet — DIETARY_SUPPLEMENT
    Subjects are provided with all food for each meal every day. The food is low in fat. In addition, subjects are provided with an oil mix that is palm oil-89%, peanut oil-6.75%, and virgin olive oil-4.25%; . They will be taught to consume the oil with each meal and mix it in with the food provided.

Study Details

In this crossover study, the investigtors will administer two experimental diets in a random order for one week, and each experimental diet will be preceded by a one-week, low fat control diet for a total four-week study period. The goal is to study how the fatty acid content of the diet affects brain functioning in healthy adults aged 65-75 years. One experimental diet will have a high palmitic acid (PA)/oleic acid (OA) ratio (HPA), typical of the North American diet. The other experimental diet will have a low PA/OA ratio (HOA), typical of the Mediterranean Diet. All allowed food and drink (except water) will be provided by the investigative team, and compliance will be enhanced by constant, intense dietary surveillance by a registered dietitian.

Key Dates

Start date
Apr 15, 2024
Status verified
Sep 2025
Primary completion
Jul 30, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: High Palmitic Acid Diet (HPA)
    Participants will ingest the HPA diet for one week. The saturated fatty acid will be high in palmitic acid which is the most prevalent saturated fatty acid in the American diet. The HPA diet will be proceeded by a one week controlled diet were the fat content is balanced between monounsaturated and saturated fatty acids.
  • Experimental: High Oleic Acid/Low Palmitic Acid Diet (HOA)
    Participants will ingest the HOA diet for one week. The monounsaturated fatty acid will be high in oleic acid which is the most prevalent monounsaturated fatty acid in the Mediterranean diet. The HOA diet will be proceeded by a one week controlled diet were the fat content is balanced between monounsaturated and saturated fatty acids.

Primary Outcome Measure

Working Memory Performance [ Time Frame: after 7 days of each diet ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VermontBurlingtonVermont05401
Jenna Makarewicz, B.S.
[email protected]
(802)847-8248
Julie Dumas, Ph.D.
[email protected]
(802)847-2523
JUlie A Dumas, Ph.D. (PRINCIPAL_INVESTIGATOR)

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University of Vermont· Burlington, VT

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