MicroRNAs as Biomarkers for Obstructive Sleep Apnea

Part of paid clinical trials in Columbus, Ohio.

Sponsor
University of Pennsylvania
Study ID
NCT06189755
Status
Recruiting
Apply to this trial

Conditions

  • Obstructive Sleep Apnea

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Positive Airway Pressure — DEVICE
    Case participants will use Positive Airway Pressure (PAP) treatment as part of routine clinical care.

Study Details

Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.

Key Dates

Start date
Apr 1, 2024
Status verified
Jul 2025
Primary completion
Nov 1, 2027
Completion
Apr 30, 2028

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Cases
    Moderate-severe OSA (defined as AHI ≥15 events/hour)
  • Arm: Controls
    No OSA (defined as AHI \<5 events/hour)

Primary Outcome Measure

microRNA [ Time Frame: Once at baseline, and after 6 months of PAP treatment, if applicable ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600ColumbusOhio43221
Ulysses J Magalang, MD
[email protected]
614-292-4307
Ulysses J Magalang, MD (PRINCIPAL_INVESTIGATOR)
University of PennsylvaniaPhiladelphiaPennsylvania19104
Colleen M Walsh, MS
[email protected]
215-614-0047
Allan I Pack, MBChB, PhD
[email protected]
215-746-4806
Allan I Pack, MBChB, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Columbus, OH

By research site
The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600· Columbus, OHUniversity of Pennsylvania· Philadelphia, PA

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