Deep Functional Phenotyping of the ALA Lung Health Cohort
Part of paid clinical trials in Birmingham, Alabama.
- Sponsor
- Johns Hopkins University
- Study ID
- NCT06177717
- Status
- Recruiting
Conditions
- Lung Diseases
Eligibility Criteria
- Sex
- ALL
- Age
- 25 Years - 35 Years
- Healthy Volunteers
- Accepted
Study Details
The goal of this observational study is to learn about lung structure and function in a group of 1000 healthy people aged 25 to 35. The main questions it aims to answer are whether people's bodies, environment, and general lung health are associated with: * the structure of the participants lungs' airways, * the structure of blood vessels in the participants lungs and heart, and * the participants lungs' ability to exchange gases. Participants will take four different lung function tests to measure lung function, including: * air movement in the lungs (oscillometry) * lung size (slow vital capacity (SVC) and functional residual capacity (FRC) * gas transfer in the lungs (diffusing capacity for carbon monoxide (DLCO).
Key Dates
- Start date
- Feb 12, 2024
- Status verified
- Mar 2026
- Primary completion
- Jul 30, 2026
- Completion
- Jul 30, 2026
Study Design
- Enrollment
- 1,000 participants (estimated)
Primary Outcome Measure
Associations with airway-parenchymal dysanapsis [ Time Frame: Baseline ]
Central Contacts
- Meredith McCormack, MD410-955-3467
- Alexis Rea, MPH443-287-8496
Locations (12)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35294 | Mark Dransfield, MD (PRINCIPAL_INVESTIGATOR) |
| University of California, Los Angeles | Los Angeles | California | 90095 | Igor Barjaktarevic, MD (PRINCIPAL_INVESTIGATOR) |
| National Jewish Health | Denver | Colorado | 80206 | Barry Make, MD (PRINCIPAL_INVESTIGATOR) |
| Nemours Children's Jacksonville | Jacksonville | Florida | 32207 | Kathryn Blake, PharmD (PRINCIPAL_INVESTIGATOR) |
| Northwestern University | Chicago | Illinois | 60611 | Ravi Kalhan, MD (PRINCIPAL_INVESTIGATOR) |
| University of Kansas | Kansas City | Kansas | 66103 | Mario Castro, MD, MPH (PRINCIPAL_INVESTIGATOR) |
| Johns Hopkins University | Baltimore | Maryland | 21218 | Nadia Hansel, MD (PRINCIPAL_INVESTIGATOR) |
| University of Michigan | Ann Arbor | Michigan | 48109 | MeiLan Han, MD (PRINCIPAL_INVESTIGATOR) |
| Duke University | Durham | North Carolina | 27710 | Loretta Que, MD (PRINCIPAL_INVESTIGATOR) |
| Wake Forest School of Medicine | Winston-Salem | North Carolina | 27104 | Wendy Moore, MD (PRINCIPAL_INVESTIGATOR) |
| University of Pittsburgh - Emphysema/COPD Research Center | Pittsburgh | Pennsylvania | 15213 | Frank Sciurba, MD (PRINCIPAL_INVESTIGATOR) |
| University of Vermont | Burlington | Vermont | 05446 | Charles Irvin, PhD (PRINCIPAL_INVESTIGATOR) |
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