Analysis of Cellular Kinases and Aging in PBMCs and Colorectal Tissue

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT06132386
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • biopsy — OTHER
    colorectal biopsy for tissue acquisition

Study Details

The goal of this clinical study is to learn about the effect of aging on certain enzymes, or proteins, in the blood and colon. The study involves collection of blood and colon tissue biopsies using a flexible sigmoidoscope or colonoscope. This study is also investigating how medications tenofovir and emtricitabine interact with certain enzymes. The investigators will compare the difference in enzyme activity between people taking tenofovir and emtricitabine, to those who are not taking tenofovir and emtricitabine.

Key Dates

Start date
Aug 7, 2023
Status verified
Dec 2025
Primary completion
May 20, 2024
Completion
May 20, 2024

Study Design

Enrollment
21 participants (actual)

Arms

  • Arm: Healthy Volunteers, not taking Tenofovir (TFV) based PrEP
  • Arm: Healthy volunteers, steady state Tenofovir (TFV) based regimen
  • Arm: Persons infected with HIV taking Tenofovir (TFV) and emtricitabine (FTC) based HIV treatment

Primary Outcome Measure

Concentration of AK2 in Colorectal Tissue [ Time Frame: Once within one month ]

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins UniversityBaltimoreMaryland21287-

Find similar trials in Baltimore, MD

By condition
HIV
By specialty
Infectious disease
By research site
Johns Hopkins University· Baltimore, MD

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