Adipose Tissue Blood Flow in Aging Humans

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT06096532
Status
Recruiting
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Conditions

  • Aging
  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • 75 gm oral glucose load — OTHER
    Consumption of 75 gm oral glucose load in order to test nutrient responsiveness

Study Details

The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults. The main question\[s\] it aims to answer are: * Is basal and nutrient responsive adipose tissue blood flow (ATBF) different between younger and older adults * What molecular and systemic signatures related to adipose tissue blood flow are altered between these two groups. Participants will undergo measurements of adipose tissue blood flow using the xenon washout technique, undergo 2 abdominal subcutaneous adipose tissue biopsies, and drink a sugary drink.

Key Dates

Start date
Feb 15, 2024
Status verified
Jan 2026
Primary completion
Dec 30, 2028
Completion
Dec 30, 2028

Study Design

Enrollment
24 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Older Adults
  • Active Comparator: Younger Adults

Primary Outcome Measure

Adipose tissue blood flow [ Time Frame: Baseline, pre-intervention fasting and immediately following 75 gm oral glucose load ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic MinnesotaRochesterMinnesota55905
Kelli A Lytle, PhD
[email protected]
507-255-1488

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