Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT06078527
Status
Not Yet Recruiting

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Conditions

  • Aspiration
  • Globus Pharyngeus
  • Iatrogenic Injury
  • Laryngeal Disease
  • Larynx Paralysis
  • Presbylarynx
  • Sensory Neuropathy
  • Spasmodic Dysphonia
  • Vocal Cord Paralysis

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Cheung-Bearelly Aesthesiometer — DEVICE
    The Cheung-Bearelly Aesthesiometer will be used to deliver a range of calibrated stimuli through the channeled flexible laryngoscope to assess sensation of the laryngopharynx.
  • Transnasal Laryngoscopy — PROCEDURE
    A procedure to examine your larynx (voice box)
  • Questionnaires — OTHER
    Patient-reported health and behavioral outcomes measures will be administered

Study Details

A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders. This study will expand on the previous research to include a separate cohort of adults being seen in clinic for an existing laryngopharyngeal disorder resulting from previous radiation or other cancer treatments.

Key Dates

Start date
Oct 1, 2025
Status verified
Jul 2025
Primary completion
Jan 31, 2028
Completion
Jan 31, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY

Arms

  • Experimental: Cancer Survivors
    Participants will attend a single 15-30 minute study session during which they will answer questionnaires (5-10 minutes) and undergo laryngopharyngeal sensory testing (10-20 minutes). There will be up to 2 years of medical record follow up after completing the main study.

Primary Outcome Measure

Percentage of participants with triggered/positive laryngeal adduction response (LAR) [ Time Frame: 1 day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, San FranciscoSan FranciscoCalifornia94143
Yue Ma
[email protected]
877-827-3222
Yue Ma, MD (PRINCIPAL_INVESTIGATOR)

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By research site
University of California, San Francisco· San Francisco, CA

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