Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine

Part of paid clinical trials in Houston, Texas.

Sponsor
The University of Texas Health Science Center, Houston
Study ID
NCT06029049
Phase
PHASE4
Status
Recruiting
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Conditions

  • Anesthesia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Modified Time Principle Induction (MTPI) with rocuronium — DRUG
    Participants will be induced using lidocaine 1 mg/kg IV, an opioid such a fentanyl (1-2 mcg/kg) IV, followed by 0.6 mg/kg IV rocuronium, and IV propofol with dosage at the discretion of the care team, administered within 10 seconds of rocuronium and the intubation will be performed with a C-MAC
  • RSI succinylcholine — DRUG
    Participants will be induced as per routine care using lidocaine 1 mg/kg IV, an opioid such a fentanyl (1-2 mcg/kg) IV, propofol 1-2 mg/kg IV, and succinylcholine 1mg/kg IV, and the intubation will be performed with a C-MAC

Study Details

The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy, vocal cord view, vocal cord opening, and movement of limbs and coughing during tracheal intubation in order to assess intubation conditions, to compare efficiency and success rate of tracheal intubation between two induction agents and to determine the rate of patient awareness during induction and post-operative recall of paralysis.

Key Dates

Start date
Sep 13, 2023
Status verified
Dec 2024
Primary completion
Jun 1, 2025
Completion
Jul 1, 2025

Study Design

Enrollment
152 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Modified Time Principle Induction (MTPI) with rocuronium
  • Active Comparator: RSI with succinylcholine

Primary Outcome Measure

Ease of laryngoscopy [ Time Frame: During procedure (Between laryngoscope insertion to onset of ventilation (less than 7 minutes)) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas Health Science Center at HoustonHoustonTexas77030
Lauren M Nakazawa, MD,MBA
[email protected]
713-500-6775
Ellie Tuchaai
[email protected]
713.614.9355

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The University of Texas Health Science Center at Houston· Houston, TX

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