Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Conditions

• Insulin Resistance
• Metabolic Disease
• Obesity
• PreDiabetes
• Type 2 Diabetes

Eligibility Criteria

Sex

ALL

Age

14 Years - 18 Years

Healthy Volunteers

Accepted

Study Details

This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.

Key Dates

Start date

Sep 6, 2023

Status verified

Jun 2026

Primary completion

Sep 30, 2027

Completion

Sep 30, 2027

Study Design

Enrollment

175 participants (estimated)

Arms

• Arm: Normal weight
  BMI ≥ 5th percentile \& \< 85th percentile
• Arm: Obese weight
  BMI ≥ 95th percentile
• Arm: PreDiabetes
  HbA1c \> 5.7%
• Arm: Type 2 Diabetes
  Diagnosed with Type 2 Diabetes
• Arm: Overweight
  BMI \> 86th percentile and \<94th percentile

Primary Outcome Measure

Glucose (OGTT) [ Time Frame: 120 minutes ]

Central Contacts

• The Singer Lab Team
  (734) 615-4938
  [email protected]

Locations (1)

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