REcovery From DEXmedetomidine-induced Unconsciousness

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT06003127
Status
Recruiting
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Conditions

  • Anesthesia
  • Consciousness, Level Altered
  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Transcranial Magnetic Stimulation-Electroencephalography — DEVICE
    Transcranial magnetic stimulation of the cerebral cortex and measurement of TMS-evoked potentials in the EEG.

Study Details

This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can be used to measure brain complexity during dexmedetomidine sedation without arousing study participants.

Key Dates

Start date
Nov 15, 2024
Status verified
Jan 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
12 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: TMS-EEG Arm
    This arm will undergo TMS-EEG during the study.
  • No Intervention: Non-TMS-EEG Arm
    This arm will not undergo TMS-EEG during the study.

Primary Outcome Measure

Time to return of responsiveness [ Time Frame: Up to 120 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02114
Emery N Brown, MD, PhD
[email protected]
617-324-1879
David Schreier, MD, PhD
[email protected]
Emery N Brown, MD, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Massachusetts General Hospital· Boston, MA

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