Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

Part of paid clinical trials in Little Rock, Arkansas.

Sponsor
Aadi Bioscience, Inc.
Study ID
NCT05997017
Phase
PHASE2
Status
Recruiting
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Conditions

  • Cancer
  • Endometrial Cancer
  • Endometrioid Endometrial Cancer
  • Endometrioid Tumor
  • Recurrent Endometrial Carcinoma
  • Tumor

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • nab-sirolimus — DRUG
    Prospective Phase 2, open-label, multi-institutional study to evaluate the efficacy and safety of nab-sirolimus + letrozole in patients

Study Details

A Phase 2 Multi-center Open-label Trial of nab-Sirolimus in Combination with Letrozole in Advanced or Recurrent Endometrioid Endometrial Cancer

Key Dates

Start date
Dec 28, 2023
Status verified
Nov 2025
Primary completion
Dec 31, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
29 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Endometrioid Endometrial Cancer
    Patients with advanced or recurrent endometrioid endometrial carcinoma

Primary Outcome Measure

Overall response rate (ORR) [ Time Frame: 12 Months ]

Central Contacts

Locations (9)

FacilityCityStateZIPSite coordinators
Michael Birrer, MD, PhDLittle RockArkansas72205
Aaron Holley
[email protected]
Matthew Kovak
[email protected]
Mount Sinai Comprehensive Cancer CenterMiami BeachFlorida33140
Michelle McClosky
[email protected]
305-674-2625
Brian Slomovitz, MD (PRINCIPAL_INVESTIGATOR)
Women's Cancer Center of NevadaLas VegasNevada89106
Thania Escamilla
[email protected]
702-693-6870
Jacky Amador
[email protected]
702-693-6870
Nicola M Spirtos, MD (PRINCIPAL_INVESTIGATOR)
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Angela Green, MD
[email protected]
646-888-4224
Angela Green, MD (PRINCIPAL_INVESTIGATOR)
Levine Cancer InstituteCharlotteNorth Carolina28204
Leah J Wilson, BS, RN, OCN
[email protected]
980-442-2333
Allison M Puechi, MD (PRINCIPAL_INVESTIGATOR)
Oklahoma University Stephenson Cancer CenterOklahoma CityOklahoma73104
Christine Pappaterra
[email protected]
405-271-8777
Lauren Dockery, MD (PRINCIPAL_INVESTIGATOR)
Women & Infants HospitalProvidenceRhode Island02905
Pamela Smith
[email protected]
401-274-1122
Cara Mathews, MD (PRINCIPAL_INVESTIGATOR)
Texas Oncology - TylerTylerTexas75702
Shelly Maxfield, CCRP
[email protected]
903-579-9840
Anna Priebe, MD (PRINCIPAL_INVESTIGATOR)
Swedish Cancer InstituteSeattleWashington98104
Anh Lam
[email protected]
206-386-2227
Fernanda Musa, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Little Rock, AR

By condition
Endometrial cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Michael Birrer, MD, PhD· Little Rock, ARMount Sinai Comprehensive Cancer Center· Miami Beach, FLWomen's Cancer Center of Nevada· Las Vegas, NVMemorial Sloan Kettering Cancer Center· New York, NYLevine Cancer Institute· Charlotte, NCOklahoma University Stephenson Cancer Center· Oklahoma City, OK

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