The Role of IL5 in Epithelial Cell Integrity

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT05895929
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Chronic Rhinosinusitis (Diagnosis)
  • Chronic Rhinosinusitis With Nasal Polyps

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Mepolizumab — DRUG
    In vitro exposure of human nasal epithelial cells to mepolizumab

Study Details

The goal of this laboratory study is the examine the effect of mepolizumab drug on the health and function of the cells lining the human nasal airways in vitro cell culture derived from patients with chronic rhinosinusitis with nasal polyposis. The main questions the study aims to study are: 1. To see what mepolizumab does to suppress inflammation of the human cells. 2. To see what mepolizumab does to maintain barrier integrity of epithelial cells

Key Dates

Start date
Sep 5, 2023
Status verified
Jan 2026
Primary completion
Dec 31, 2025
Completion
Jun 30, 2026

Study Design

Enrollment
8 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Mepolizumab treatment arm
    Nasal epithelial cells will be exposed in vitro to mepolizumab in culture.
  • No Intervention: Control arm
    Nasal epithelial cells will be exposed in vitro to media without mepolizumab in culture

Primary Outcome Measure

Change in Type 1 inflammatory markers (ng/mL) [ Time Frame: 0 to 48 hours ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Johns Hopkins Bayview Medical CenterBaltimoreMaryland21117
Jean Kim, MD PhD
[email protected]
410-550-0460
Hyun Sil Lee, PhD
[email protected]
410-550-2064
Johns Hopkins HospitalBaltimoreMaryland21287
Jean Kim, MD PhD
[email protected]
410-550-0460
Hyun Lee, PhD
[email protected]
410-550-2064

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Johns Hopkins Bayview Medical Center· Baltimore, MDJohns Hopkins Hospital· Baltimore, MD

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