Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT04469439
Status
Recruiting
Apply to this trial

Conditions

  • Chronic Rhinosinusitis (Diagnosis)
  • Cystic Fibrosis

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

Key Dates

Start date
Jul 1, 2020
Status verified
Jul 2025
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
170 participants (estimated)

Arms

  • Arm: Surgical group
    Individuals with cystic fibrosis and chronic rhinosinusitis who undergo endoscopic sinus surgery
  • Arm: Medical group
    Individuals with cystic fibrosis and chronic rhinosinusitis who do not undergo endoscopic sinus surgery

Primary Outcome Measure

Change in pulmonary function [ Time Frame: baseline, 3, 6, 9, 12 months ]

Central Contacts

Locations (9)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095
Marlene Florian
[email protected]
Daniel M Beswick, MD (PRINCIPAL_INVESTIGATOR)
Stanford UniversityStanfordCalifornia94305-
University of ColoradoAuroraColorado80045-
National Jewish HealthDenverColorado80206-
University of North CarolinaChapel HillNorth Carolina27514-
Oregon Health Science UniversityPortlandOregon97239-
Medical University of South CarolinaCharlestonSouth Carolina29425-
Vanderbilt University Medical CenterNashvilleTennessee37232-
University of UtahSalt Lake CityUtah84132-

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By research site
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