Stimulation-Induced Changes in Fronto-Limbic Network

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
University of Alabama at Birmingham
Study ID
NCT05854160
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Electrical Pulse Train Stimulation — PROCEDURE
    sEEG provides the ability to stimulate neural circuits via implanted electrodes by delivering mild intra-cranial electrical stimulations in different brain structures to estimate their impact on cognitive tasks.

Study Details

The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.

Key Dates

Start date
Mar 1, 2023
Status verified
Feb 2026
Primary completion
Feb 28, 2026
Completion
Mar 24, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Acquisition Stimulation Test
    Single pulse stimulation will be delivered and measured prior to the rating task. Next, subjects perform the Pavlovian fear conditioning paradigm. Participants will be asked to perform a rating task automated on a PC where they continuously update a rating bar using the touchpad to indicate their confidence that a static sound is about to occur on a moment-by-moment basis (0-not confident to 100-very confident). For the stimulation experiment, research staff will explain that electrical stimulation will be applied before the rating task, in isolation, as well as on some trials at controlled time points while the patient performs the rating task

Primary Outcome Measure

Fronto-limbic connectivity and autonomic or expectation responses [ Time Frame: 20 Minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Epilepsy Monitoring Unit UAB HospitalBirminghamAlabama35233
Rebekah Chatfield, BS
[email protected]
(205) 975 3477
Adam Goodman, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Birmingham, AL

By condition
Epilepsy
By specialty
NeurologyBrain disorders
By research site
Epilepsy Monitoring Unit UAB Hospital· Birmingham, AL

Related Studies